Reagent used in peptide synthesis, as an additive to suppress racemization.
Cat#
CR-03
CAS No
12 3333-53-9
Molecular formula
C6H5N3O·H2O
Molecular weight
135 + 18
Appearance
White crystalline powder
Purity (HPLC)
99% min.
Melting Point
153-159ºC
HOBt
was proposed as an additive to DCC
to reduce racemization. Today, majority of peptide drugs
up to 13-15 amino acids are synthesized using solution approach,
Boc chemistry and conventional DCC/
HOBt method
